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Users are welcome to use the "guest" account (password "anonymous") but they should be aware that all analyses on this account are removed each night. Further, all results are visible to other users.

News

March 2009

Specific Histone Databases

Databases have been created for all Top Down observed forms of Histone H4 and Histone H3.2 for homo sapiens.

Coming Soon: Middle-Down/Bottom-Up Warehouses for Unit Resolution Data

Digested proteome warehouses will soon be available. These ProSight warehouses are unique in that they retain all of the PTM, alternative splice and SNP information found in our intact protein warehouses on the peptide level giving users the ability to search peptide tandem MS data for valuable PTMs.

We now have over 500 users!

Please continue to give us feedback to update and improve ProSightPTM.

ProSight PTM 2.0 Published in Nucleic Acids Research

A article describing the new features in ProSight PTM 2.0 can be found on-line:

ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry
Leonid Zamdborg; Richard D. LeDuc; Kevin J. Glowacz; Yong-Bin Kim; Vinayak Viswanathan; Ian T. Spaulding; Bryan P. Early; Eric J. Bluhm; Shannee Babai; Neil L. Kelleher
Nucleic Acids Research 2007; doi: 10.1093/nar/gkm371

ProteinMassRanger

A tool for determining all protein forms in a ProSight proteome warehouse that have a theoretical mass within a user-specified tolerance of a given value

Overview

Welcome

ProSight PTM 2.0 allows identification and characterization of both intact proteins and peptides. Our ProSight Warehouses are annotated with all known post-translational modifications (PTMs), alternative splicing events and single nucleotide polymorphisms (SNPs) using the technique of Shotgun Annotation developed in the Kelleher Research Group. ProSightPTM is the only proteomics software that allows the user to search their tandem MS data against proteome warehouses containing the known biological complexity present in UniProt.

Don't guess where the PTMs are, use ProSight.

neuroPeptidomics

If your research involves the analysis of neuropeptides, please visit neuroProSight for the unique ability to search for neuropeptides against an annotated prohormone warehouse. neuroProSight is supported by the UIUC Center for Neuroproteomics on Cell-Cell Signaling funded by the National Institute on Drug Abuse Grant P30 DA 018310.

Access

Generate your free ProSightPTM2 account.

Supported Warehouses

The list of currently supported proteome warehouses is available here. Let us know if you have any proteome warehouse requests.

Acknowledgements

Dr. John Garavelli is assisting us by incorporating the RESID database of post-translational modifications. We gratefully acknowledge these sources of generous support:

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